Pitt | Swanson Engineering

久9视频这里只有精品_自拍亚洲_俺去啦线视频在线观看The Chemical and Petroleum Engineering department at the University of Pittsburgh Swanson School of Engineering was established in 1910, making it the first department for petroleum engineering in the world. Today, our department has over 40 expert faculty (tenure/tenure-stream/joint/adjunct), a host of dedicated staff, more than 20 state-of-the-art laboratories and learning centers, and education programs that enrich with strong fundamentals and hands-on experience.

Chemical engineering is concerned with processes in which matter and energy undergo change. The range of concerns is so broad that the chemical engineering graduate is prepared for a variety of interesting and challenging employment opportunities.

Chemical engineers with strong background in sciences are found in management, design, operations, and research. Chemical engineers are employed in almost all industries, including food, polymers, chemicals, pharmaceutical, petroleum, medical, materials, and electronics. Since solutions to energy, environmental, and food problems must surely involve chemical changes, there will be continued demands for chemical engineers in the future.

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Mimicking Cancer to Avoid Transplant Rejection

Bioengineering, Chemical & Petroleum

Originally published by UPMC Media Relations. Reposted with permission. PITTSBURGH – Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own. Rats that were treated with these cell-sized microparticles developed permanent immune tolerance to grafts — including a whole limb — from a donor rat, while keeping the rest of their immune system intact, according to a paper published today in Science Advances. “It’s like hacking into the immune system borrowing a strategy used by one of humanity’s worst enemies to trick the body into accepting a transplant,” said senior author Steven Little, Ph.D., William Kepler Whiteford Endowed Professor and Chair of chemical and petroleum engineering in the Swanson School of Engineering at Pitt. “And we do it synthetically.” The advantage of a synthetic approach rather than cell-based therapy, which is currently in clinical trials, is that the treatment logistics are much simpler. “Instead of isolating cells from a patient, growing them up in the lab, injecting them back in and hoping they find the right location, we’re packaging it all up in an engineered system that recruits these naturally occurring cells right to the transplanted graft,” said lead author James Fisher, M.D., Ph.D., a postdoctoral researcher in the Pitt School of Medicine. The microparticles work by releasing a native protein secreted by tumors, CCL22, which draws regulatory T cells (Treg cells) to the site of the graft, where they tag the foreign tissue as “self” so that it evades immune attack. Microparticle-treated animals maintained healthy grafts for as long as they were monitored — a little under a year, equivalent to about 30 human years. All it took was two shots to effect seemingly permanent change. In a companion paper published recently in PNAS, the researchers showed that these engineered microparticles can train the immune system of one strain of rat to accept a donor limb from a different strain. This new paper shows that the effects are specific to the intended donor. Skin grafts from a third strain were rapidly rejected. Today, transplant patients take daily doses of immunosuppressant drugs to avoid rejection, leaving them vulnerable to cancer, diabetes, infectious diseases and a host of other ailments that come along with a weakened immune system. “These drugs hammer the immune system into submission so it can’t attack the transplanted organ, but then it can’t protect the body either,” said coauthor Stephen Balmert, Ph.D., a postdoctoral researcher in the Pitt School of Medicine. “We’re trying to teach the immune system to tolerate the limb, so that a transplant recipient can remain immunocompetent.” The risks of lifelong immunosuppression are particularly problematic when the transplant isn’t a life-saving procedure. Doctors and patients have to consider whether the benefits outweigh the risks. “The ability to induce transplant tolerance while avoiding systemic immunosuppression, as demonstrated in these innovative studies, is especially important in the context of vascularized composite transplantation where patients receive quality-of-life transplants, such as those of hands or face,” said coauthor Angus Thomson, Ph.D., professor of surgery and immunology in the Thomas E. Starzl Transplantation Institute at Pitt. Additional authors on the study include Wensheng Zhang, Ph.D., Ali Aral, M.D., Abhinav Acharya, Ph.D., Yalcin Kulahci, M.D., Jingjing Li, M.D., Heth Turnquist, Ph.D., Mario Solari, M.D., all of Pitt; and Vijay Gorantla, M.D., Ph.D., of the Wake Forest School of Medicine. This research was supported by the National Institute of Allergy and Infectious Diseases (R01-AI118777 U19-AI131453, R01-HL122489, T32-AI074490), National Institute of Dental and Craniofacial Medicine (R01-DE021058), the Department of Defense (W81XWH-15-2-0027 and W81XWH-15-1-0244), The Camille & Henry Dreyfus Foundation and the National Cancer Institute (T32-CA175294).
Author: Erin Hare, Ph.D., Manager, Science Writing

Learn more about Pitt's planning and response to COVID-19

Bioengineering, Chemical & Petroleum, Civil & Environmental, Electrical & Computer, Industrial, MEMS, Diversity, Student Profiles, Office of Development & Alumni Affairs

Please visit and bookmark the University of Pittsburgh COVID-19 site for the most up-to-date information and a full list of resources. From the University Times: As the coronavirus COVID-19 continues to spread around the world, Pitt is remaining diligent with addressing related issues as the pop up. For an overall look at updates from Pitt, go to emergency.coralskeppelbaypreview.com. On Saturday, Provost Ann Cudd issued a statement about how to support faculty and staff who have committed to attending professional conferences this semester and choose not to attend due to the COVID-19 outbreak. The University will grant an exception for travel booked through May 31 and reimburse any out-of-pocket expenses incurred by those who decide to cancel travel. The administration will reassess this deadline date as COVID-19 evolves and may extend the deadline as conditions evolve. For more updates from the provost, go to provost.coralskeppelbaypreview.com. The provost and the University Center for Teaching and Learning is encouraging faculty to be prepared if remote learning situations become required. The center has set up a page detailing the basics of providing instructional continuity. The page will be updated regularly. Find information about remote learning and more at teaching.coralskeppelbaypreview.com/instructional-continuity. All business units and responsibilities centers also are being asked to work on how to handle mass absenteeism and/or the need for as many people as possible to work at home.


Associate or Full Professor, Tenure Stream

Chemical & Petroleum, Open Positions

We seek one exceptional tenured candidate for a position at associate or full professor level. Our department is re-establishing an ABET-accredited BS degree program in PetE to complement our MS in PetE, and the applicant is expected to provide leadership in the development of the undergraduate curriculum and internship/coop program.  Promising academic candidates must have a track record of leadership in Petroleum Engineering research and contributions to teaching Petroleum Engineering courses at the undergraduate or graduate levels. We also welcome industrial candidates with at least five years of experience reflected in an extensive research and presentation record, along with university-level instructional experience. All candidates, whether from academia or industry, must have a PhD in science or engineering and at least one degree (BS, MS or PhD) in Petroleum Engineering. Candidates from groups traditionally underrepresented in engineering are strongly encouraged to apply. Our department has internationally recognized programs in Energy and Sustainability, Catalysis and Reaction Engineering, Materials, Multi-Scale Modeling, and Biomedical Engineering. Active collaborations exist with several adjacent centers, including the U.S. DOE National Energy Technology Laboratory, the University of Pittsburgh Center for Simulation and Modeling, the Center for Energy, the Petersen Institute for Nanoscience and Engineering, the Mascaro Center for Sustainable Innovation, the University of Pittsburgh Medical Center, and the McGowan Institute for Regenerative Medicine.  Our department has a strategic alliance with Lubrizol Corporation that includes educational and research components. The candidate is expected to lead a vibrant research program (funded by federal sources such as NSF, DOE and NETL, state agencies, industry partners, ACS PRF, etc.). The successful applicant will be expected to organize and lead large group proposals and to develop a strong relationship with the NETL facilities in Pittsburgh and Morgantown and with regional gas and oil producing companies. The candidate must also be committed to high quality teaching for a diverse student body and to assisting our department in enhancing diversity. To apply, please submit via Interfolio a detailed CV, names of four references, research plans/vision (5 - 10 pages), teaching plans/vision (2 - 4 pages), and service plans/vision (2 - 4 pages related to professional service to the department, university and scientific community).  Applications will only be accepted via submission through the following Interfolio link: http://apply.interfolio.com/73466. To ensure full consideration, applications must be received by May 1, 2020. Please address any inquiries (but not applications) to Dr. Robert Enick via che@coralskeppelbaypreview.com. Please put “2020 PetE position” in the subject line. The University of Pittsburgh is an EEO/AA/M/F/Vet/Disabled employer.

Pitt PetE Search

Shining a New Light on Biomimetic Materials

Chemical & Petroleum

PITTSBURGH (February 24, 2020) … Advances in biomimicry – creating biological responses within non-biological substances – will enable synthetic materials to behave in ways that were typically only found in Nature. Light provides an especially effective tool for triggering life-like, dynamic responses within a range of materials. The problem, however, is that the applied light is typically dispersed throughout the sample and thus, it is difficult to localize the bio-inspired behavior to the desired, specific portions of the material. A convergence of optical, chemical and materials sciences, however, has yielded a novel way to utilize light to control the local dynamic behavior within a material. In a general sense, the illuminated material mimics a vital biological behavior: the ability of the iris and pupil in the eye to dynamically respond to the incoming light. Furthermore, once the light enters the sample, the material itself modifies the behavior of the light, trapping it within regions of the sample. The latest research from the University of Pittsburgh’s Swanson School of Engineering, Harvard University and McMaster University, reveals a hydrogel that can respond to optical stimuli and modify the stimuli in response. The group’s findings of this opto-chemo-mechanical transduction were published this month in the Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.1902872117). The Pitt authors include Anna C. Balazs, Distinguished Professor of Chemical and Petroleum Engineering and John A. Swanson Chair of Engineering; and Victor V. Yashin, Visiting Research Assistant Professor. Other members include Joanna Aizenberg, Amos Meeks (co-first author) and Anna V. Shneidman, Wyss Institute for Biologically Inspired Engineering and Harvard John A. Paulson School of Engineering and Applied Sciences; Ankita Shastri, Harvard Department of Chemistry and Chemical Biology; and Fariha Mahmood, Derek Morim (co-first author), Kalaichelvi Saravanamuttu and Andy Tran, McMaster University, Ontario, Canada. “Until only a decade or so ago, the preferred state for materials was static. If you built something, the preference was that a material be predictable and unchanging,” Dr. Balazs explained. “However, as technology evolves, we are thinking about materials in new ways and how we can exploit their dynamic properties to make them responsive to external stimuli. “For example, rather than programming a computer to make a device perform a function, how can we combine chemistry, optics and materials to mimic biological processes without the need for hard-wired processors and complex algorithms?”The findings continue Dr. Balazs’ research with spiropyran (SP)-functionalized hydrogels and the material’s photo-sensitive chromophores. Although the SP gel resembles gelatin, it is distinctive in its ability to contain beams of light and not disperse them, similar to the way fiber optics passively control light for communication. However, unlike a simple polymer, the water-filled hydrogel reacts to the light and can “trap” the photons within its molecular structure. “The chromophore in the hydrogel plays an important role,” she explains. “In the absence of light, the gel is swollen and relaxed. But when exposed to light from a laser beam about the width of a human hair, it changes it structure, shrinks and becomes hydrophobic. This increases the polymer density and changes the hydrogel’s index of refraction and traps the light within regions that are denser than others. When the laser is removed from the source, the gel returns to its normal state. The ability of the light to affect the gel and the gel in turn to affect the propagating light creates a beautiful feedback loop that is unique in synthetic materials.” Most surprisingly, the group found that the introduction of a second, parallel beam of light creates a type of communication within the hydrogel. One of the self-trapped beams not only controls a second beam, but also the control can happen with a significant distance between the two, thanks to the response of the hydrogel medium. Dr. Yashin notes that this type of control is now possible because of the evolution of materials, not because of advances in laser technology.“The first observation of self-trapping of light occurred in 1964, but with very large, powerful lasers in controlled conditions,” he said. “We can now more easily achieve these behaviors in ambient environments with far less energy, and thus greatly expand the potential use for non-linear optics in applications.”The group believes that opto-chemo-mechanical responses present a potential sandbox for exploration into soft robotics, optical computing and adaptive optics. “There are few materials designed with a built-in feedback loop,” Dr. Balazs said. “The simplicity of the responses provides an exciting way to mimic biological processes such as movement and communication, and open new pathways toward creating devices that aren’t reliant on human control.”This research was supported in part by the US Army Research Office under Award W911NF-17-1-0351 and by the Natural Sciences and Engineering Research Council, Canadian Foundation for Innovation. ### Schematic representation of optical self-trapping within SP-functionalized hydrogels with two remote beams; each beam is switched on and off to control the interaction. (Aizenberg/Saravanamuttu Lab. Proceedings of the National Academy of Sciences Feb 2020, 201902872; DOI: 10.1073/pnas.1902872117) SP-modified hydrogels. (A) Photoisomerization scheme of chromophore substituents from the protonated merocyanine (MCH+, Left) to SP (Right) forms in the methylenebis(acrylamide) cross-linked p(AAm-co-AAc) hydrogel. (B) Photographs of chromophore-containing p(AAm-co-AAc) hydrogel monoliths employed in experiments. (C) UV-visible absorbance spectra demonstrating reversible isomerization of MCH+ (absorption λmax = 420 nm) to SP (λmax = 320 nm) in solution. (D) Experimental setup (Top) to probe laser self-trapping due to photoinduced local contraction of the hydrogel, schematically depicted on the Bottom (see also Movie S1). A laser beam is focused onto the entrance face of the hydrogel while its exit face is imaged onto a CCD camera. (Aizenberg/Saravanamuttu Lab. Proceedings of the National Academy of Sciences Feb 2020, 201902872; DOI: 10.1073/pnas.1902872117)


Pitt ChemE Professor Awarded Sloan Research Fellowship

Chemical & Petroleum

PITTSBURGH (Feb. 12, 2020) — Susan Fullerton, PhD, Bicentennial Board of Visitors Faculty Fellow and assistant professor of chemical engineering at the University of Pittsburgh’s Swanson School of Engineering, has been selected as a 2020 Alfred P. Sloan Research Fellow in Chemistry. The highly competitive award is given to outstanding early-career scientists from the U.S. and Canada. The two-year, $75,000 fellowship recognizes researchers’ unique potential to make substantial contributions to their field. Fullerton’s fellowship will further her research on two-dimensional materials for next-generation electronics.  These two-dimensional materials can be thought of as a piece of paper – if the paper were only a single molecule thick.  Fullerton’s group uses ions to control charge in these molecularly thin sheets for application in memory and logic.  Fullerton is the 12th Pitt faculty member to receive the Chemistry Fellowship since 1970 “This Fellowship speaks to Susan’s groundbreaking research in electronics, and how she’s used her training in the chemical sciences to impact this field; it’s an honor that is well-deserved,” says Steven Little, PhD, William Kepler Whiteford Professor and Department Chair of Chemical and Petroleum Engineering. The Sloan Research Fellowships are awarded annually to 126 researchers in the areas of chemistry, computation and evolutionary molecular biology, computer science, economics, mathematics, neuroscience, ocean sciences and physics. The Alfred P. Sloan Foundation, founded in 1934 and named for the former president and CEO of the General Motors Corporation, makes grants to support research and education in science, technology, engineering, mathematics and economics.
Maggie Pavlick

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